Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

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Anxiogenic effect of low-dose methamphetamine in the test of elevated plus-maze.

Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate f...

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Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...

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ژورنال

عنوان ژورنال: Prague Medical Report

سال: 2012

ISSN: 1214-6994,2336-2936

DOI: 10.14712/23362936.2015.20